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Wednesday, May 22, 2013

By studying the roles two proteins, thrombospondin-1 and prosaposin, play in discouraging cancer metastasis, a trans-Atlantic research team has identified a five-amino acid fragment of prosaposin that significantly reduces metastatic spread in mouse models of prostate, breast and lung cancer. The findings suggest that a prosaposin-based drug could potentially block metastasis in a variety of cancers.

The study team, led by Randolph Watnick, PhD, at Boston Children’s Hospital, Vivek Mittal, PhD, at Weill Cornell Medical College and Lars Akslen, MD, PhD, at the University of Bergen, released their findings in the May issue of the journal Cancer Discovery.

The main cause of cancer mortality is not the primary tumor itself, but rather its spread?metastasis?to other locations in the body and subsequent organ failure. Previous studies by Watnick, a member of Boston Children’s Vascular Biology Program, and others have shown that tumors capable of metastasis release proteins that help prepare new homes in distant organs for their metastatic progeny.

Watnick’s lab has also previously shown that tumors that cannot metastasize release prosaposin. This protein activates expression of a second protein called thrombospondin-1, a potent anti-angiogenic factor, in tissues where metastatic tumor cells could potentially take root. Thrombospondin-1 makes these otherwise-permissive tissues resistant to metastasis.

“In the past, we’ve struggled to determine the source of thrombospondin-1 production,” Watnick says. “We knew it was coming from the tumor microenvironment, normal cells adjacent to the sites of potential metastasis, but we could not tell if those cells were native to the microenvironment or had been recruited from the bone marrow.”

Using mouse models of breast, prostate and lung cancer, Watnick and his colleagues confirmed through bone marrow transplant and gene knockout experiments that both metastatic and non-metastatic tumors induce cells from the bone marrow?specifically, monocytes expressing the Gr1 surface marker?to migrate to the lungs. However, non-metastatic tumors then trigger these monocytes to produce thrombospondin-1 by releasing prosaposin.

“Others have shown that tumors recruit monocytes to future metastatic sites, which help to set up a permissive environment for tumor cells to metastasize, ” Watnick notes. “Our results suggest that non-metastatic tumors do the same thing, but instead of creating a permissive environment, the monocytes create a refractory environment by producing thrombospondin-1.”

Watnick thinks this finding creates a window of therapeutic opportunity. “If we can trigger monocytes recruited by pro-metastatic tumors to produce thrombospondin-1 like those recruited by non-metastatic tumors, we will be able to hijack the mechanism by which tumors create metastasis-permissive sites to close the door on those sites.”

Thrombospondin-1 itself, however, is too large to serve as a drug, and studies using shortened versions of the protein have not been promising. Watnick and his collaborators instead are focusing on prosaposin. To find the smallest part of prosaposin capable of activating thrombospondin-1, the team took an 80-amino acid region of prosaposin and whittled it down bit by bit until they isolated a five amino-acid peptide that could trigger thrombospondin-1 production as strongly as the full-length protein.

When administered in mouse models of metastatic cancer, this peptide significantly reduced metastasis compared to scrambled versions of the peptide (with the same amino acids but in different sequence), but only in mice with monocytes capable of producing thrombospondin-1.

Strikingly, Watnick and his collaborators also found that prostate cancer patients whose tumors expressed higher levels of prosaposin had significantly greater overall survival than patients whose tumors expressed low levels of prosaposin. Thus, with additional work, Watnick believes the prosaposin peptide could be the foundation for a tumor- and location-agnostic method of treating or preventing metastasis in patients with advanced cancers.

“The size of this peptide makes it ideal for drug development,” Watnick says. “It’s about as large as tyrosine kinase inhibitors such as Gleevec or Iressa, and could potentially be formulated in multiple ways for different types of cancer. I could also foresee using a therapeutic agent like this peptide as an adjuvant therapy, for example just as we now use chemotherapy or hormonal therapy for breast cancer.”

Boston Children’s Technology and Innovation Development Office (TIDO) has filed patent applications on these peptides, peptide derivatives and their uses. A start-up company is in the works.

###

Boston Children’s Hospital: http://www.childrenshospital.org/newsroom

Thanks to Boston Children’s Hospital for this article.

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Source: http://www.labspaces.net/128350/Changing_cancer_s_environment_to_halt_its_spread

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NORTH WEBSTER, Ind. (AP) ? Northern Indiana authorities say more than 45 middle and high school students were injured and a bus driver was seriously hurt in a chain-reaction crash involving four school buses.

Kosciusko (kahs-ee-AHS’-koh) Community Hospital spokeswoman Joy Lohse (LOH’-see) says 43 people injured in the accident were being treated there. She says none are in serious or critical condition. She didn’t have any information on how many of them were students or the patients’ exact conditions. A nursing supervisor at IU Health Goshen Hospital says four students being treated there are in good condition.

The accident happened around 3:30 p.m. Wednesday. Sheriff’s Department Sgt. Chad Hill says authorities don’t know yet the cause of the accident. He says one bus apparently was stopped to let a student off when it occurred.

Source: http://news.yahoo.com/45-students-hurt-chain-reaction-ind-bus-crash-225104562.html

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10 Ways to avoid Viruses and Spyware

To have a fighting chance against today?s rampant security threats, end users have to be informed and proactive. Here are some practical guidelines you can follow to minimize the risk of infection and attack.

What is a Computer Virus?: A Computer Virus is simply a computer program with malicious intent. These programs are usually small in size, and the more clever ones hide themselves within other innocent programs (e.g. within NOTEPAD), hence the ?virus? in their name. In fact the technical difference between a Computer Virus and a Computer Worm is that the virus inserts itself within some other legitimate program, while the Worm exists as a standalone program. From a user?s perspective, this distinction is somewhat moot, and a worm or a virus can do equal damage. In fact the word ?worm? is used less these days, and virus is often applied to both types of programs.

Viruses are usually written by students with time on their hands, though a few are very sophisticated and obviously written by professionals (disgruntled employees, frustrated programmers etc.). While there are over 30,000 known computer viruses, the number of truly original viruses is actually quite limited, as seen by the number of copy-cat viruses that proliferate after any well-publicized virus incident. For example, there are apparently several hundred variants of the ?ILoveYou? virus out there. Most are just plain copies, or minor variations of the original.

As a ICT professional responsible for securing office networks, workstations, and servers from viruses, spyware, adware, Trojans, and other malware infections, I can tell you that the situation is only getting worse.

A Computer Economics report showed that, annual worldwide malware expenses increased by $10 billion (to $13 billion) over a recent 10-year span. Google Research suggests that one in every 10 Web sites is infected with ?drive-by? malware. In June 2009, the Windows Secrets e-newsletter reported that such seemingly safe Web sites as Coldwell Banker.com, Variety.com, and even Tennis.com were exposing Internet Explorer visitors to the Gambler exploit, which threatens to compromise visitors? systems in order to propagate.

IT professionals must encourage their users to follow several security practices to minimize virus, spyware, and malware exposure. But many computer techs are too busy to spread the word, or they don?t have the time to build an appropriate memo or handout.

With that in mind, here?s a handy reference list of 10 steps end users can adopt to avoid infection (including when using home systems to read and send work e-mail, create, edit, and distribute documents and spreadsheets, access the corporate VPN, and perform other office tasks). Post this list on your Intranet, distribute it in an e-mail, or download the PDF version ?at www.diyict.com.ng and pass it along to end users. Just be sure the word gets out. Otherwise, you?re likely to find yourself losing precious time cleaning and repairing infected systems or entire networks.

1: Install quality antivirus

Many computer users believe free antivirus applications, such as those included with an Internet service provider?s bundled service offering, are sufficient to protect a computer from virus or spyware infection. However, such free anti-malware programs typically don?t provide adequate protection from the ever-growing list of threats.

Instead, all Windows users should install professional, business-grade antivirus software on their PCs. Pro-grade antivirus programs update more frequently throughout the day (thereby providing timely protection against fast-emerging vulnerabilities), protect against a wider range of threats (such as rootkits), and enable additional protective features (such as custom scans).

2: Install real-time anti-spyware protection

Many computer users mistakenly believe that a single antivirus program with integrated spyware protection provides sufficient safeguards from adware and spyware. Others think free anti-spyware applications, combined with an antivirus utility, deliver capable protection from the skyrocketing number of spyware threats.

Unfortunately, that?s just not the case. Most free anti-spyware programs do not provide real-time, or active, protection from adware, Trojan, and other spyware infections. While many free programs can detect spyware threats once they?ve infected a system, typically professional (or fully paid and licensed) anti-spyware programs are required to prevent infections and fully remove those infections already present.

3: Keep anti-malware applications current

Antivirus and anti-spyware programs require regular signature and database updates. Without these critical updates, anti-malware programs are unable to protect PCs from the latest threats.

In early 2009, antivirus provider AVG released statistics revealing that a lot of serious computer threats are secretive and fast-moving. Many of these infections are short-lived, but they?re estimated to infect as many as 100,000 to 300,000 new Web sites a day.

Computer users must keep their antivirus and anti-spyware applications up to date. All Windows users must take measures to prevent license expiration, thereby ensuring that their anti-malware programs stay current and continue providing protection against the most recent threats. Those threats now spread with alarming speed, thanks to the popularity of such social media sites as Twitter, Facebook, and My Space.

4: Perform daily scans

Occasionally, virus and spyware threats escape a system?s active protective engines and infect a system. The sheer number and volume of potential and new threats make it inevitable that particularly inventive infections will outsmart security software. In other cases, users may inadvertently instruct anti-malware software to allow a virus or spyware program to run.

Regardless of the infection source, enabling complete, daily scans of a system?s entire hard drive adds another layer of protection. These daily scans can be invaluable in detecting, isolating, and removing infections that initially escape security software?s attention.

5: Disable autorun

Many viruses work by attaching themselves to a drive and automatically installing themselves on any other media connected to the system. As a result, connecting any network drives, external hard disks, or even thumb drives to a system can result in the automatic propagation of such threats.

Computer users can disable the Windows autorun feature by following Microsoft?s recommendations, which differ by operating system. Microsoft Knowledge Base articles 967715 and 967940 are frequently referenced for this purpose.

6: Disable image previews in Outlook

Simply receiving an infected Outlook e-mail message, one in which graphics code is used to enable the virus? execution, can result in a virus infection. Prevent against automatic infection by disabling image previews in Outlook.

By default, newer versions of Microsoft Outlook do not automatically display images. But if you or another user has changed the default security settings, you can switch them back (using Outlook 2007) by going to Tools | Trust Center, highlighting the Automatic Download option, and selecting Don?t Download Pictures Automatically In HTML E-Mail Messages Or RSS.

7: Don?t click on email links or attachments

It?s a mantra most every Windows user has heard repeatedly: Don?t click on email links or attachments. Yet users frequently fail to heed the warning.

Whether distracted, trustful of friends or colleagues they know, or simply fooled by a crafty email message, many users forget to be wary of links and attachments included within email messages, regardless of the source. Simply clicking on an email link or attachment can, within minutes, corrupt Windows, infect other machines, and destroy critical data.

Users should never click on email attachments without at least first scanning them for viruses using a business-class anti-malware application. As for clicking on links, users should access Web sites by opening a browser and manually navigating to the sites in question.

8: Surf smart

Many business-class anti-malware applications include browser plug-ins that help protect against drive-by infections, phishing attacks (in which pages purport to serve one function when in fact they try to steal personal, financial, or other sensitive information), and similar exploits. Still others provide ?link protection,? in which Web links are checked against databases of known-bad pages.

Whenever possible, these preventive features should be deployed and enabled. Unless the plug-ins interfere with normal Web browsing, users should leave them enabled. The same is true for automatic pop-up blockers, such as are included in Internet Explorer 8, Google?s toolbar, and other popular browser toolbars.

Regardless, users should never enter user account, personal, financial, or other sensitive information on any Web page at which they haven?t manually arrived. They should instead open a Web browser, enter the address of the page they need to reach, and enter their information that way, instead of clicking on a hyperlink and assuming the link has directed them to the proper URL. Hyperlinks contained within an e-mail message often redirect users to fraudulent, fake, or unauthorized Web sites. By entering Web addresses manually, users can help ensure that they arrive at the actual page they intend.

But even manual entry isn?t foolproof. Hence the justification for step 10: Deploy DNS protection. More on that in a moment.

9: Use a hardware-based firewall

Technology professionals and others argue the benefits of software- versus hardware-based firewalls. Often, users encounter trouble trying to share printers, access network resources, and perform other tasks when deploying third-party software-based firewalls. As a result, I?ve seen many cases where firewalls have simply been disabled altogether.

But a reliable firewall is indispensable, as it protects computers from a wide variety of exploits, malicious network traffic, viruses, worms, and other vulnerabilities. Unfortunately, by itself, the software-based firewall included with Windows isn?t sufficient to protect systems from the myriad robotic attacks affecting all Internet-connected systems. For this reason, all PCs connected to the Internet should be secured behind a capable hardware-based firewall.

10: Deploy DNS protection

Internet access introduces a wide variety of security risks. Among the most disconcerting may be drive-by infections, in which users only need to visit a compromised Web page to infect their own PCs (and potentially begin infecting those of customers, colleagues, and other staff).

Another worry is Web sites that distribute infected programs, applications, and Trojan files. Still another threat exists in the form of poisoned DNS attacks, whereby a compromised DNS server directs you to an unauthorized Web server. These compromised DNS servers are typically your ISP?s systems, which usually translate friendly URLs such as yahoo.com to numeric IP addresses like 69.147.114.224.

Users can protect themselves from all these threats by changing the way their computers process DNS services. While a computer professional may be required to implement the switch, OpenDNS offers free DNS services to protect users against common phishing, spyware, and other Web-based hazards.

Engr. ?Femi Akinsanya is the Author of

DIY ICT Training Laboratory Manuals

?for Educational Institutions in Nigeria

?and the African Continent.

This article was written by admin

Source: http://diyict.com.ng/2013/05/20/10-ways-to-avoid-viruses-and-spyware/

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BEIJING (AP) ? China‘s new leader Xi Jinping will confer with President Barack Obama next month in California, months earlier than their expected first meeting, as both sides seek to stem a drift in relations, troubled by issues from cyberspying to North Korea.

The June 7-8 meeting at a retreat southeast of Los Angeles, announced Monday by the White House, underlines the importance of the relationship between the countries as they work out ways for the U.S.-led world order to make room for a China that is fast accruing global influence and military power.

Xi has said that China wants its rise to be peaceful, but that Beijing will not compromise on issues of sovereignty ? a stance that has aggravated disputes over contested East and South China Seas islands with U.S. allies Japan and the Philippines and friend Vietnam.

Among the other pressing items on their agenda: the spotty global economic recovery, U.S. allegations of persistent Chinese cyber-attacks and espionage and Washington’s desire for China to do more in international efforts to curb North Korea’s nuclear program.

The issues are so many that the agenda was becoming crowded for any Obama and Xi meeting. The two leaders have spoken by telephone since Obama was re-elected and Xi elevated to Communist Party chief in November. But their first face-to-face meeting was not expected to be held until September on the sidelines of the summit of the Group of 20 large economies in Russia.

“They needed more than 20 minutes on the sidelines of another meeting,” said Bonnie Glaser of the Center for Strategic and International Studies in Washington. “If they want to see U.S.-China relations on a solid footing, to manage the differences and find issues to cooperate on ? North Korea, Iran, climate change ? it has to start at the top. U.S. China relations are not managed from the bottom up but from the top down.”

The White House, in its statement, said the two presidents will “discuss ways to enhance cooperation, while constructively managing our differences, in the years ahead.”

Chinese Foreign Ministry spokesman Qin Gang said that “this meeting is important to the long-term, sound and steady development of China-US relations as well as regional and international peace, stability and prosperity.”

The decision to hold a working visit instead of a pomp-filled state summit also underscores the government’s decision to put protocol aside to focus on substance. Xi will make the stop-off in California after traveling to Trinidad and Tobago, Costa Rica and Mexico.

“The engagement has become more flexible, and that helps keep the contact at the highest levels, which is conducive to understanding each other’s viewpoints and taking more effective measures,” Zhu Feng, deputy director of the Center for International and Strategic Studies at Peking University.

U.S. diplomats have said that Chinese officials had wanted Obama to come to Beijing late this year or early next. His last visit was in 2009. Since then, Xi went to Washington in early 2012 as vice president, and his predecessor as president, Hu Jintao, was given a formal White House welcome a year earlier.

To prepare for the California meeting, Obama’s national security adviser, Tom Donilon, will go to Beijing on May 26-28, White House press secretary Jay Carney said.

Source: http://news.yahoo.com/chinas-xi-meet-obama-earlier-expected-032851953.html

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NEW YORK (AP) ? Stock indexes are edging higher in midday trading on Wall Street as investors look ahead to the Federal Reserve‘s next moves.

The Dow Jones industrial average was up 32 points at 15,367 at noon Eastern Daylight Time Tuesday, a gain of 0.2 percent.

The Standard & Poor’s 500 index was up a point at 1,667, or 0.08 percent. The Nasdaq composite was up two points at 3,498, or 0.05 percent.

Home Depot rose 2 percent, or $1.64, to $78.40 after the home improvement retailer reported an 18 percent increase in income for its first quarter as the housing market continued to recover.

JPMorgan rose 89 cents or 1.7 percent to $53.17. Shareholders are voting on a measure that would split the roles of chairman and CEO.

Source: http://news.yahoo.com/indexes-edge-higher-wall-street-midday-trade-155914289.html

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In this photo Thursday, April 25, 2013 Lucy Butler,15, getting ready to have her measles jab at All Saints School in Ingleby Barwick, Teesside, England, as a national vaccination catch-up campaign has been launched to curb a rise in measles cases in England. More than a decade ago, British parents refused to give measles shots to at least a million children because of a vaccine scare that raised the specter of autism. Now, health officials are scrambling to catch up and stop a growing epidemic of the contagious disease. (AP Photo/Owen Humphreys, PA) UNITED KINGDOM OUT – NO SALES – NO ARCHIVES

In this photo Thursday, April 25, 2013 Lucy Butler,15, getting ready to have her measles jab at All Saints School in Ingleby Barwick, Teesside, England, as a national vaccination catch-up campaign has been launched to curb a rise in measles cases in England. More than a decade ago, British parents refused to give measles shots to at least a million children because of a vaccine scare that raised the specter of autism. Now, health officials are scrambling to catch up and stop a growing epidemic of the contagious disease. (AP Photo/Owen Humphreys, PA) UNITED KINGDOM OUT – NO SALES – NO ARCHIVES

In this photo taken on Thursday, May 9 2013, Ellen Christensen poses for a photograph with her six-week-old son Remy at the Ann Tayler Children Centre in east London. More than a decade ago, British parents refused to give measles shots to at least a million children because of a vaccine scare that raised the specter of autism. Now, health officials are scrambling to catch up and stop a growing epidemic of the contagious disease. This year, the U.K. has had more than 1,200 cases of measles, after a record number of nearly 2,000 cases last year. The country once recorded only several dozen cases every year. It now ranks second in Europe, behind only Romania. (AP Photo/Matt Dunham)

LONDON (AP) ? More than a decade ago, British parents refused to give measles shots to at least a million children because of now discredited research that linked the vaccine to autism. Now, health officials are scrambling to catch up and stop a growing epidemic of the contagious disease.

This year, the U.K. has had more than 1,200 cases of measles, after a record number of nearly 2,000 cases last year. The country once recorded only several dozen cases every year. It now ranks second in Europe, behind only Romania.

Last month, emergency vaccination clinics were held every weekend in Wales, the epicenter of the outbreak. Immunization drives have also started elsewhere in the country, with officials aiming to reach 1 million children aged 10 to 16.

“This is the legacy of the Wakefield scare,” said Dr. David Elliman, spokesman for the Royal College of Paediatrics and Child Health, referring to a paper published in 1998 by Andrew Wakefield and colleagues that is widely rejected by scientists.

That work suggested a link between autism and the combined childhood vaccine for measles, mumps and rubella, called the MMR. Several large scientific studies failed to find any connection, the theory was rejected by at least a dozen major U.K. medical groups and the paper was eventually retracted by the journal that published it.

Britain’s top medical board stripped Wakefield of the right to practice medicine in the U.K., ruling that he and two of his colleagues showed a “callous disregard” for the children in the study, subjecting them to unnecessary, invasive tests. As part of his research, Wakefield took blood samples from children at his son’s birthday party, paying them about 5 pounds each ($7.60), and later joked about the incident.

Still, MMR immunization rates plummeted across the U.K. as fearful parents abandoned the vaccine ? from rates over 90 percent to 54 percent. Wakefield has won support from parents suspicious of vaccines, including Hollywood celebrities like Jenny McCarthy, who has an autistic son.

Nearly 15 years later, the rumors about MMR are still having an impact. Now there’s “this group of older children who have never been immunized who are a large pool of infections,” Elliman said.

The majority of those getting sick in the U.K. ? including a significant number of older children and teens ? had never been vaccinated. Almost 20 of the more than 100 seriously ill children have been hospitalized and 15 have suffered complications including pneumonia and meningitis. One adult with measles has died, though it’s unclear if it was the disease that killed him.

The first measles vaccines were introduced in the 1960s, which dramatically cut cases of the rash-causing illness. Since 2001, measles deaths have dropped by about 70 percent worldwide; Cambodia recently marked more than a year without a single case.

Globally, though, measles is still one of the leading causes of death in children under 5 and kills more than 150,000 people every year, mostly in developing countries. Measles is highly contagious and is spread by coughing, sneezing and close personal contact with infected people; symptoms include a fever, cough, and a rash on the face.

Across the U.K., about 90 percent of children under 5 are vaccinated against measles and have received the necessary two doses of the vaccine. But among children now aged 10 to 16, the vaccination rate is slightly below 50 percent in some regions.

To stop measles outbreaks, more than 95 percent of children need to be fully immunized. In some parts of the U.K., the rate is still below 80 percent.

Unlike in the United States, where most states require children to be vaccinated against measles before starting school, no such regulations exist in Britain. Parents are advised to have their children immunized, but Britain’s Department of Health said it had no plans to consider introducing mandatory vaccination.

Last year, there were 55 reported cases of measles in the United States, where the measles vaccination rate is above 90 percent. So far this year, there have been 22 cases, including three that were traced to Britain. In previous years, the U.K. has sometimes exported more cases of measles to the U.S. than some countries in Africa.

Portia Ncube, a health worker at an East London clinic, said the struggle to convince parents to get the MMR shot is being helped by the measles epidemic in Wales.

“They see what’s happening in Wales, so some of them are now sensible enough to come in and get their children vaccinated,” she said.

Clinic patient Ellen Christensen, mother of an infant son, acknowledged she had previously had some “irrational qualms” about the MMR vaccine.

“But after reading more about it, I know now that immunization is not only good for your own child, it’s good for everyone,” she said.

___

Online:

Public Health England’s Measles website:

http://www.hpa.org.uk/Topics/InfectiousDiseases/InfectionsAZ/Measles/

___

AP Medical Writer Mike Stobbe in New York contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-05-20-Britain%20Measles/id-7c53569ea3844d5ba7db189c45e9beab

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BOSTON (AP) ? Cardinal Sean O’Malley skipped Boston College‘s commencement Monday to protest its decision to honor Irish Prime Minister Enda Kenny, who backs legislation to permit abortion, and O’Malley’s views were echoed outside the ceremony by a few dozen anti-abortion activists.

The protesters gathered at an entrance to the stadium where Kenny gave the keynote address and received an honorary degree, with some holding signs saying it was a scandal that the Catholic school was hosting Kenny.

The bill Kenny supports allows abortion only if a doctor authorizes it to save a woman’s life. But opponents say it would lead to widespread abortions because of a provision that permits it if a woman threatens suicide.

Protester C.J. Doyle of the Catholic Action League called that “the proverbial Mack truck loophole” and said Boston College’s decision to honor Kenny undermines the church’s anti-abortion teachings.

“What rational person can reasonably be expected to take seriously Catholic opposition to abortion when our own Catholic institutions honor someone who’s trying to legalize abortion in his country?” he said.

Kenny didn’t mention the controversy during his keynote address.

Afterward, Kenny told reporters the bill does nothing to change an 1861 Irish law that makes abortion a crime punishable by life in prison.

Instead, the bill “is setting out clarity and legal certainty, that is intended to save lives, not to end them,” he said.

In 1992, Ireland’s Supreme Court ruled abortion should be legal if doctors determine it’s needed to save the woman’s life. In 1992 and 2002, voters rejected two referendums to allow abortion to stop a physical threat to a woman’s life, not including suicide.

The current bill is being debated following last year’s death of a woman who was hospitalized at the start of a protracted miscarriage during her 17th week of pregnancy. Doctors refused her request for an abortion and she died of massive organ failure.

The bill permits a single doctor to authorize an abortion if the woman’s life is in immediate danger. Two doctors must approve if a pregnancy poses a potentially lethal risk. The approval of three doctors is required if the woman is threatening suicide.

O’Malley announced he’d skip Boston College’s graduation earlier this month, saying Irish bishops had concluded the bill “represents a dramatic and morally unacceptable change to Irish law,” and noting that U.S. bishops have asked Catholic institutions not to honor officials who promote abortion.

Boston College spokesman Jack Dunn said Monday that Kenny’ s invitation was unrelated to the controversial legislation and was offered solely because of historical ties between his country and a school founded by an Irish Jesuit to serve Irish immigrants.

He said the invitation to Kenny in no way erodes the school’s anti-abortion stance.

“Boston College as a Catholic institution fully supports the church’s commitment to the unborn,” he said.

Source: http://news.yahoo.com/boston-cardinal-skips-event-over-irish-pms-role-145156916.html

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Well, Yahoo! has already officially announced its $1.1 billion cash deal to snatch up social darling and microblogging platform du jour, Tumblr. The question on everyone’s mind is, what else could the struggling web pioneer have up it’s sleeve? Truth is we have no idea. Could Mayer have another acquisition to announce or a special new product lined up for tonight’s event? Or, is she simply going to talk about the finer details of the Tumblr deal for an hour. You’ll have to check back in at 5:00pm ET to find out.

Yahoo! NYC press event

Filed under: Internet

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Source: http://www.engadget.com/2013/05/20/yahoos-press-event-is-live-tonight/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Posted about 4 hours ago | Onepakistannews

KARACHI National Forum for Environment and Health (NFEH) has invited nominations for 10th? Annual Environment Excellence Awards (AEEA 2013) to industries and other business organizations following environment friendly guidelines and performance for promoting the cause of pollution-free environment.

This was announced by Chairman NFEH Dr Kaiser Waheed and Secretary Award Committee Ruqiya Naeem in the meeting of NFEH Advisory Committee held at NFEH Office. He said awards were instituted 10 years ago and have lured a very enthusiastic response from the industry. These awards have become the benchmark for the standards that need to be followed. The AEEA are designed to recognize and promote the organizations which make an outstanding contribution towards sustainable development.

They aim to highlight policies, practices, processes and products from all sectors of business in the country, which help achieve economic and social development without damaging environment and natural resources, he added

He said Governor Sindh, Federal Minister, Provincial Minister on Environment and representative of United Nations would also participate in the event. On this occasion, a special edition of Monthly Energy Update Magazine highlighting the role of award winning organizations would also be distributed among the participants.

On 10th Year celebrations, a environment gallery is being organized schools. NGO S ,Environmental projects, green energy project .environmental products will be displayed their projects and products .in the gallery. to appreciate civil society , schools , media and environmentalist will be honored.

Interested organizations may obtain the criteria of AEEA Form from NFEH office by JUNE 07, 2013, and submission date is June 7, 2013.

Source: http://pakistan.onepakistan.com.pk/news/breaking/211692-nfeh-invites-nominations-for-environment-excellence-awards.html

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